The pharmaceutical industry has become a large and very complex enterprise.

Since its inception at the beginning of the 19th century, this industry has transformed into one of the most profitable and most influential industries considered to be one of the largest investors in research and development both at European and worldwide level, a globally connected market of healthcare.

The pharmaceutical industry is operating on a highly profitable market, with large profit margins, differentiated, of course depending on the size of the business and the stage of development. Business challenges have imposed to adjust their business models to fit the new market requirements to ensure business success.

How have Romanian companies behaved in the globalized business environment, and which is the level of profitability needed to ensure sustainability? To these questions the present study is looking to bring answers to.