The aim of this paper is to highlight the link between the regional science and the regional development from
EU. With the focus on the region, regional science has experienced, over 50 years of existence, different forms of
manifestation, but also periods of progress and decay. One of its important features is multidisciplinarity, which
provides it a special status. The current period offers it an opportunity of outstanding manifestation, regarding regional
development, allowing it to combine theoretical and practical research. Thus, among others, regional science can
provide a theoretical and methodological basis for the objectives of reducing the regional imbalances.